There is risk of over- and undertreating patients with ambiguous melanocytic tumors because it is implicitly not known which lesion is benign and which is malignant. ![]() There is a paucity of literature on these lesions and their management. 11 Atypical melanocytic proliferations often involve expert consultation and require management based on a review of the clinical situation and favored opinions by pathologists. A lack of standardized diagnostic terminology makes it challenging to gauge clinical behavior and guide treatment. When evaluating an atypical melanocytic proliferation, pathologists may not be able to establish a definitive diagnosis and/or disagree with each other on the nature of the tumor. ![]() 1– 10 These lesions are often referred to as atypical melanocytic proliferations. Most histological diagnoses involving melanocytic lesions can be made with a high level of certainty, reproducibility, and agreement among dermatopathologists however, there exists a subset of melanocytic neoplasms that can be difficult to classify as benign or malignant based on conventional microscopic analysis. ![]() Early detection of melanoma is key from a patient prognosis standpoint, and as such the authors rely on an accurate histopathological assessment.
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